Chloroquine Induced Oxidative Stress in Male Albino Mice: RCT

Many drugs have been found to induce oxidative stress. Oxidative stress is responsible for a large number of diseases. Chloroquine one the drugs, which can stress, when it given at higher dose. Purpose: To find effect chloroquine as inducer on albino mice. Study Design: Randomized clinical trial. Methodology: Sixty male mice were taken into this randomized controlled study. Those divided two groups 30 each. Group A was control group while B single oral dose 970 mg/kg body weight 9th day experiment. Terminal intracardiac blood sample obtained 17th Statistical analysis: SPSS version 23 used data analysis. Results: When results compared with those A, there highly significant (p= 0.000) rise in serum malondialdehyde level and decrease glutathione peroxidase level. Conclusion: It concluded that induces Keywords: Chloroquine, Stress Malondialdehyde.